abstract：:Pneumococcal polysaccharide conjugate vaccine (13-valent, adsorbed) (PCV13; Prevenar 13(®); Prevnar 13(®)) is approved in adults aged ≥50 years (focus of review) and in children aged 6 weeks to 5 years for protection against pneumococcal diseases caused by Streptococcus pneumoniae in numerous countries worldwide, incl...

journal_title：Drugs & aging

authors： Scott LJ,Sanford M

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Medication non-adherence can exacerbate disease severity, leading to impairments that interfere with self-care activities in older adults, and, ultimately, death. Elder self-neglect is the most common report to Adult Protective Services (APS) across the USA and is a significant risk factor for early mortalit...

journal_title：Drugs & aging

authors： Turner A,Hochschild A,Burnett J,Zulfiqar A,Dyer CB

更新日期：2012-09-01 00:00:00

abstract：:Adverse drug reactions (ADRs) in older adults are an important healthcare problem since they are frequently a cause of hospitalization, occur commonly during admission, and are an important cause of morbidity and mortality. Older adults are particularly susceptible to ADRs because they are usually on multiple drug reg...

journal_title：Drugs & aging

authors： Petrovic M,van der Cammen T,Onder G

更新日期：2012-06-01 00:00:00

abstract：:Lithium salts have a well-established role in the treatment of major affective disorders. More recently, experimental and clinical studies have provided evidence that lithium may also exert neuroprotective effects. In animal and cell culture models, lithium has been shown to increase neuronal viability through a combi...

journal_title：Drugs & aging

authors： Forlenza OV,de Paula VJ,Machado-Vieira R,Diniz BS,Gattaz WF

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Patient transitions, such as transfers between acute and long-term care (LTC), aposare times when the likelihood of communication failure between healthcare providers is increased. Employing appropriate health quality indicators helps support improvement efforts. To date, few quality indicators that evaluate...

journal_title：Drugs & aging

authors： Bell CM,Brener SS,Comrie R,Anderson GM,Bronskill SE

更新日期：2012-04-01 00:00:00

abstract：:Falls are a common health problem for older people, and psychotropic medications have been identified as an important independent fall risk factor. The objective of this paper was to review the literature relating to the effect of psychotropic medications on falls in older people, with a particular focus on evidence s...

journal_title：Drugs & aging

authors： Hill KD,Wee R

更新日期：2012-01-01 00:00:00

abstract：:CATT (Comparison of Age-related macular degeneration [AMD] Treatment Trials) examined the efficacy of ranibizumab and bevacizumab for the treatment of neovascular AMD. This prospective, randomized, but unblinded trial revealed a significant improvement in vision with both treatments in terms of visual acuity; importan...

journal_title：Drugs & aging

authors： Ziemssen F,Sobolewska B

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Antidepressant medications have long been implicated as a cause of falls in older people, but there are few data on the risk of falls associated with exposure to serotonin-norepinephrine (noradrenaline) reuptake inhibitors (SNRIs). OBJECTIVE:The aim of this study was to determine the role of SNRIs in older ...

journal_title：Drugs & aging

authors： Gribbin J,Hubbard R,Gladman J,Smith C,Lewis S

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Optimal use of digoxin in the elderly population requires information about the drug's pharmacokinetics and the influence of various factors on the drug's disposition. However, because of sampling restrictions, it is often difficult to perform traditional pharmacokinetic studies in elderly patients. OBJECTI...

journal_title：Drugs & aging

authors： Yukawa M,Yukawa E,Suematsu F,Takiguchi T,Ikeda H,Aki H,Mimemoto M

更新日期：2011-10-01 00:00:00

abstract：:The main characteristic of acute lymphoblastic leukaemia (ALL) in the elderly is its dismal prognosis. However, other than a lower incidence of T-cell ALL and a greater likelihood of unfavourable chromosomal abnormalities, the clinical and biological characteristics of Philadelphia chromosome-negative (Ph-) ALL in the...

journal_title：Drugs & aging

authors： Rousselot P,Delannoy A

更新日期：2011-09-01 00:00:00

abstract：:Giant cell arteritis (GCA) is an inflammatory vasculopathy that involves large- and medium-sized arteries and can cause vision loss, stroke and aneurysms. GCA occurs in people aged >50 years and is more common in women. A higher incidence of the disease is observed in populations from Northern European countries. Poly...

journal_title：Drugs & aging

authors： Schmidt J,Warrington KJ

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Use of combination pharmacotherapy, including angiotensin-converting enzyme (ACE) inhibitors, angiotensin II type 1 receptor antagonists (angiotensin receptor blockers) and β-adrenoceptor antagonists (β-blockers) in the management of heart failure (HF) can reduce mortality, prevent functional decline and red...

journal_title：Drugs & aging

authors： Foebel AD,Heckman GA,Hirdes JP,Tyas SL,Tjam EY,McKelvie RS,Maxwell CJ

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Reduced renal function increases the risk of adverse drug reactions (ADRs) to hydrosoluble drugs (hADRs). However, the ability of different equations to calculate estimated glomerular filtration rate (eGFR) or estimated creatinine clearance (eCCr) and thereby predict the risk of developing hADRs has not prev...

journal_title：Drugs & aging

authors： Corsonello A,Pedone C,Lattanzio F,Onder G,Antonelli Incalzi R,Gruppo Italiano di Farmacovigilanza nell'Anziano (GIFA).

更新日期：2011-05-01 00:00:00

abstract：:Chronic non-terminal diseases, including postmenopausal osteoporosis, are associated with poor treatment compliance and persistence. The longer a patient with osteoporosis complies and persists with treatment, the lower the risk of fracture. Retrospective studies with emphasis on real-world data have led to a greater ...

journal_title：Drugs & aging

authors： Gold DT

更新日期：2011-04-01 00:00:00

abstract：:Elderly people with renal impairment are at high risk for venous thromboembolism (VTE) and acute coronary syndromes (ACS); however, they are also at increased risk for bleeding complications. Evidence-based data for the management of anticoagulation in elderly patients with severe renal impairment, in particular, are ...

journal_title：Drugs & aging

authors： Samama MM

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Overactive bladder syndrome (OAB) is associated with various co-morbidities; treatment of these frequently results in multiple medication use (MMU) and the potential for drug-drug interactions, which may lead to adverse events and altered efficacy. With the aging population, the prevalence of MMU is likely t...

journal_title：Drugs & aging

authors： Sand PK,Rovner ES,Watanabe JH,Oefelein MG

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Medication-related problems are common in the growing population of older adults and inappropriate prescribing is a preventable risk factor. Explicit criteria such as the Beers criteria provide a valid instrument for describing the rate of inappropriate medication (IM) prescriptions among older adults. OBJE...

journal_title：Drugs & aging

authors： Blozik E,Born AM,Stuck AE,Benninger U,Gillmann G,Clough-Gorr KM

更新日期：2010-12-01 00:00:00

abstract：:Atrial fibrillation confers a 5-fold increase in risk of stroke. A number of drugs aimed at reducing this risk have been tested in randomized controlled trials. These include antiplatelet agents (singly and in combination); anticoagulants, including vitamin K antagonists and direct thrombin inhibitors; and anticoagula...

journal_title：Drugs & aging

authors： Mant J,Edwards D

更新日期：2010-11-01 00:00:00

abstract：INTRODUCTION:Congestive heart failure (CHF), which typically affects older people, is characterized by high short- and mid-term mortality rates. However, despite accumulating evidence showing that administration of β-blockers (β-adrenoceptor antagonists) can improve the clinical status of CHF patients, use of these age...

journal_title：Drugs & aging

authors： Antonicelli R,Mazzanti I,Abbatecola AM,Parati G

更新日期：2010-10-01 00:00:00

abstract：:Prostate cancer is a common disease in the elderly, and the number of older prostate cancer patients will probably increase with both the aging of the population and the increased rate of screening. In elderly patients with several co-morbidities, cancer management can be complex, and the risk of administering toxic t...

journal_title：Drugs & aging

authors： Fontana A,Falcone A,Derosa L,Di Desidero T,Danesi R,Bocci G

更新日期：2010-09-01 00:00:00

abstract：:Although inflammatory bowel disease (IBD) is generally considered a disease of young adults, it can occur in elderly individuals. The clinical features and treatment considerations in older patients are similar to those in younger patients, with some notable exceptions, which are reviewed in this article. Consideratio...

journal_title：Drugs & aging

authors： Hussain SW,Pardi DS

更新日期：2010-08-01 00:00:00

abstract：INTRODUCTION:Older cancer patients are possibly at an increased risk of medication-related problems because, typically, they receive many medications during their cancer treatment, both for the cancer itself and for supportive care. OBJECTIVES:The aim of this study was to describe the number and severity of potential ...

journal_title：Drugs & aging

authors： Puts MT,Monette J,Girre V,Costa-Lima B,Wolfson C,Batist G,Bergman H

更新日期：2010-07-01 00:00:00

abstract：:High drug consumption among the elderly and inappropriate prescribing practices increase the risk of adverse drug effects in this population. This risk may be decreased by conducting, for example, a medication review alone or as part of a comprehensive geriatric assessment (CGA); however, little is known about the fat...

journal_title：Drugs & aging

authors： Lampela P,Hartikainen S,Lavikainen P,Sulkava R,Huupponen R

更新日期：2010-06-01 00:00:00

abstract：:Multiple sclerosis (MS) is an acquired inflammatory demyelinating disease of the CNS that is typically diagnosed in the second or third decade of life. It is generally believed that over the last few decades the life expectancy of patients with adult onset MS (AOMS) has approached that of the general population as a r...

journal_title：Drugs & aging

authors： Awad A,Stüve O

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Osteoporosis is a common cause of disability and death in elderly men and women. Until 2007, Australian Government-subsidized use of oral bisphosphonates, raloxifene and calcitriol (1alpha,25-dihydroxycholecalciferol) was limited to secondary prevention (requiring x-ray evidence of previous low-trauma fractu...

journal_title：Drugs & aging

authors： Hollingworth SA,Gunanti I,Nissen LM,Duncan EL

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Despite evidence of effective combination drug therapy for secondary prevention of coronary heart disease (CHD), older adults with this condition remain undertreated. OBJECTIVE:To describe time trends (1992-2003) in the adoption of combination cardiac drug therapies (beta-blockers [beta-adrenoceptor antagon...

journal_title：Drugs & aging

authors： Tjia J,Briesacher B,Xie D,Fu J,Goldberg RJ

更新日期：2010-02-01 00:00:00

abstract：:Cataract surgery is the most frequent surgical procedure requiring anaesthesia in developed countries. It is performed mainly in elderly patients, who present with many coexisting diseases that induce subsequent hazards from general anaesthesia. Cataract anaesthesia is performed following various techniques of regiona...

journal_title：Drugs & aging

authors： Nouvellon E,Cuvillon P,Ripart J,Viel EJ

更新日期：2010-01-01 00:00:00

abstract：:Chronic pain occurs in 45-85% of the geriatric population and the need to treat chronic pain is growing substantially. Unfortunately, treatment for chronic pain is not always correctly targeted, which leads to a reduced quality of life, with decreased socialization, depression, sleep disturbances, cognitive impairment...

journal_title：Drugs & aging

authors： Gianni W,Ceci M,Bustacchini S,Corsonello A,Abbatecola AM,Brancati AM,Assisi A,Scuteri A,Cipriani L,Lattanzio F

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:The number of elderly patients with oesophageal cancer is expected to increase with the aging of the population and the rapidly increasing incidence of adenocarcinoma. Surgical resection is standard treatment for patients with localized disease considered fit for operation. However, elderly patients with oes...

journal_title：Drugs & aging

authors： Servagi-Vernat S,Bosset M,Crehange G,Buffet-Miny J,Puyraveau M,Maingon P,Mercier M,Bosset JF

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Several studies have suggested that NSAID use may modify the risk of developing Parkinson's disease (PD). OBJECTIVE:Our aim was to conduct a meta-analysis of observational studies evaluating NSAID use and the risk of PD. METHODS:We systematically searched MEDLINE (1966-November 2008), EMBASE (1980-November...

journal_title：Drugs & aging

authors： Samii A,Etminan M,Wiens MO,Jafari S

更新日期：2009-01-01 00:00:00

abstract：:In contrast with the earlier stages and, in particular, the predementia stage, of Alzheimer's disease (AD), severe dementia is often neglected. However, the advanced stages of dementia are just as important as the earlier stages because of their frequency, their impact on the lives of patients and their caregivers, an...

journal_title：Drugs & aging

authors： Voisin T,Vellas B

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Medication-related admissions are an important cause of hospital admissions in older people. The scope for prevention is less clear. OBJECTIVES:To characterize medication-related hospital admissions in older people and assess their preventability. METHODS:This was a cross-sectional, observational study con...

journal_title：Drugs & aging

authors： Rogers S,Wilson D,Wan S,Griffin M,Rai G,Farrell J

更新日期：2009-01-01 00:00:00

abstract：:Antidepressants have long been recognized as a contributory factor to falls and many studies show an association between antidepressants and falls. There are extensive data for tricyclic antidepressants (TCAs) and related drugs, and for selective serotonin reuptake inhibitors (SSRIs), but few data for other classes of...

journal_title：Drugs & aging

authors： Darowski A,Chambers SA,Chambers DJ

更新日期：2009-01-01 00:00:00

abstract：:Despite a sharp decline in the incidence of gastric cancer during the second half of the 20th century, this malignancy remains the second leading cause of cancer mortality in the world. The incidence and mortality rate of gastric cancer increase with age; at present, the median ages at diagnosis are 67 years for men a...

journal_title：Drugs & aging

authors： Wagner AD,Wedding U

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The practice of hiding medicines in nursing home patients' food or beverages is described in only a few scientific papers. An earlier study conducted in 1999/2000 showed that covert medication was common in Norwegian nursing homes, with 11% of patients in regular nursing home units (RUs) and 17...

journal_title：Drugs & aging

authors： Kirkevold O,Engedal K

更新日期：2009-01-01 00:00:00

abstract：:Patients with chronic kidney disease (CKD) are generally affected by secondary hyperparathyroidism (SHPT). High phosphate, low calcium and vitamin D deficiency represent the classical 'triad' involved into the pathogenesis of SHPT in renal insufficiency, in which downregulation of the parathyroid vitamin D receptor an...

journal_title：Drugs & aging

authors： Cozzolino M,Gallieni M,Pasho S,Fallabrino G,Ciceri P,Volpi EM,Olivi L,Brancaccio D

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Because of co-morbidity, older persons are often exposed to use of an excessive number of drugs, which per se implies also use of inappropriate drugs or of potentially interacting drugs ('suboptimal prescribing'). Time trends of suboptimal prescribing in older, community dwellers have been poorly investigate...

journal_title：Drugs & aging

authors： Lapi F,Pozzi C,Mazzaglia G,Ungar A,Fumagalli S,Marchionni N,Geppetti P,Mugelli A,Di Bari M

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Older people are often prescribed multiple drugs with sedative properties. Most research has focused on specific classes of sedative and psychotropic drugs. The cumulative effect of taking multiple drugs with sedative properties has been termed 'sedative load'. Few previous studies have investigated the seda...

journal_title：Drugs & aging

authors： Taipale HT,Bell JS,Soini H,Pitkälä KH

更新日期：2009-01-01 00:00:00

abstract：:The objective of this review is to evaluate the usefulness of oral cobalamin (vitamin B12) treatment in elderly patients. PubMed was systematically searched for English and French articles published from January 1990 to January 2007. Prospective randomized studies (n=3), a systematic review by the Cochrane group (n=1)...

journal_title：Drugs & aging

authors： Andrès E,Vogel T,Federici L,Zimmer J,Kaltenbach G

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Benzodiazepines are frequently used medications in the elderly, in whom they are associated with an increased risk of falling, with sometimes dire consequences. OBJECTIVE:To estimate the impact of benzodiazepine-associated injurious falls in a population of elderly persons. METHOD:A nested case-control stu...

journal_title：Drugs & aging

authors： Pariente A,Dartigues JF,Benichou J,Letenneur L,Moore N,Fourrier-Réglat A

更新日期：2008-01-01 00:00:00